Relationship between trough plasma and epithelial lining fluid concentrations of voriconazole in lung transplant recipients.
نویسندگان
چکیده
Trough (predose) voriconazole concentrations in plasma and pulmonary epithelial lining fluid (ELF) of lung transplant recipients receiving oral voriconazole preemptive treatment were determined. The mean (± standard deviation [SD]) ELF/plasma ratio was 12.5 ± 6.3. A strong positive linear relationship was noted between trough plasma and ELF voriconazole concentrations (r(2) = 0.87), suggesting the feasibility of using trough plasma voriconazole concentration as a surrogate to estimate the corresponding concentration in ELF of lung transplant recipients.
منابع مشابه
Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimen.
Voriconazole penetrated well into the pulmonary epithelial lining fluid (ELF) in lung transplant patients receiving oral prophylaxis. The ELF concentrations exceeded those of the plasma, with an average ELF-to-plasma ratio of 11 (+/-8). A strong association between plasma and ELF concentrations (r(2) = 0.95) was noted.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 57 9 شماره
صفحات -
تاریخ انتشار 2013